psilocin


SMILES CN(CCc1c[nH]c2c1c(O)ccc2)C
InChIKey SPCIYGNTAMCTRO-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 2
Hydrogen bond donors 2
Rotatable bonds 3
Molecular weight (Da) 204.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Structure pdb 9AS8 8DPG 7WC5 9LL8 9AS7
Ligand site mutations 5-HT2A 5-HT2C

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT1E 5HT1E Human 5-Hydroxytryptamine A pKi 7.36 7.36 7.36 ChEMBL
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 6.52 6.52 6.52 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 8.33 8.34 8.34 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 6.25 6.72 7.2 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 6.47 6.8 6.97 ChEMBL
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 7.72 7.72 7.72 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 6.85 6.85 6.85 ChEMBL
5-HT5A 5HT5A Human 5-Hydroxytryptamine A pKi 7.16 7.16 7.16 ChEMBL
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 7.14 7.14 7.14 ChEMBL
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 7.14 7.14 7.14 ChEMBL
D1 DRD1 Human Dopamine A pKi 7.7 7.7 7.7 ChEMBL
D3 DRD3 Human Dopamine A pKi 7.0 7.0 7.0 ChEMBL
A2A AA2AR Human Adenosine A pKi 5.7 5.7 5.7 ChEMBL
A2B AA2BR Human Adenosine A pKi 5.89 5.89 5.89 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT2A 5HT2A Mouse 5-Hydroxytryptamine A pEC50 8.0 8.0 8.01 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pEC50 7.24 7.24 7.24 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pIC50 8.97 8.97 8.97 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pIC50 6.71 6.71 6.71 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pEC50 5.24 7.56 8.37 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pIC50 6.45 7.16 8.08 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pEC50 7.52 7.52 7.52 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pIC50 8.11 8.11 8.11 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pEC50 7.62 7.62 7.62 Guide to Pharmacology