prazosin
| SMILES | COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 |
| InChIKey | IENZQIKPVFGBNW-UHFFFAOYSA-N |
Chemical properties
| Hydrogen bond acceptors | 8 |
| Hydrogen bond donors | 1 |
| Rotatable bonds | 4 |
| Molecular weight (Da) | 383.2 |
Drug properties
| Molecular type | Small molecule |
| Physiological/Surrogate | Surrogate |
| Approved drug | Yes |
Bioactivities
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
| α1A | ADA1A | Human | Adrenoceptors | A | pKi | 9.0 | 9.45 | 9.9 | Guide to Pharmacology |
| α1D | ADA1D | Human | Adrenoceptors | A | pKi | 9.1 | 9.65 | 10.2 | Guide to Pharmacology |
| α2B | ADA2B | Human | Adrenoceptors | A | pKi | 6.2 | 6.85 | 7.5 | Guide to Pharmacology |
| α2C | ADA2C | Human | Adrenoceptors | A | pKi | 6.5 | 7.25 | 8.0 | Guide to Pharmacology |
| α1A | ADA1A | Rat | Adrenoceptors | A | pKi | 9.5 | 9.5 | 9.5 | Guide to Pharmacology |
| 5-HT1D | 5HT1D | Human | 5-Hydroxytryptamine | A | pKi | 8.02 | 8.02 | 8.02 | Drug Central |
| 5-HT2A | 5HT2A | Human | 5-Hydroxytryptamine | A | pKi | 8.11 | 8.11 | 8.11 | Drug Central |
| 5-HT2B | 5HT2B | Human | 5-Hydroxytryptamine | A | pKi | 8.25 | 8.25 | 8.25 | Drug Central |
| α1A | ADA1A | Human | Adrenoceptors | A | pKi | 7.98 | 7.98 | 7.98 | Drug Central |
| α1B | ADA1B | Human | Adrenoceptors | A | pKi | 8.01 | 8.01 | 8.01 | Drug Central |
| α2A | ADA2A | Human | Adrenoceptors | A | pKi | 8.18 | 8.18 | 8.18 | Drug Central |
| α2B | ADA2B | Human | Adrenoceptors | A | pKi | 8.1 | 8.1 | 8.1 | Drug Central |
| α2C | ADA2C | Human | Adrenoceptors | A | pKi | 8.12 | 8.12 | 8.12 | Drug Central |
| D4 | DRD4 | Human | Dopamine | A | pKi | 8.29 | 8.29 | 8.29 | Drug Central |
| 5-HT2A | 5HT2A | Rat | 5-Hydroxytryptamine | A | pKi | 8.24 | 8.24 | 8.24 | Drug Central |
| α1D | ADA1D | Rat | Adrenoceptors | A | pKi | 8.01 | 8.01 | 8.01 | Drug Central |
| μ | OPRM | Rat | Opioid | A | pKi | 8.01 | 8.01 | 8.01 | Drug Central |
| α1B | ADA1B | Rat | Adrenoceptors | A | pKi | 8.0 | 8.0 | 8.0 | Drug Central |
| 5-HT1A | 5HT1A | Rat | 5-Hydroxytryptamine | A | pKi | 8.25 | 8.25 | 8.25 | Drug Central |
| α1A | ADA1A | Rat | Adrenoceptors | A | pKi | 7.99 | 7.99 | 7.99 | Drug Central |
| α2A | ADA2A | Pig | Adrenoceptors | A | pKi | 8.27 | 8.27 | 8.27 | Drug Central |
| α2A | ADA2A | Bovine | Adrenoceptors | A | pKi | 8.16 | 8.16 | 8.16 | Drug Central |
| α2A | ADA2A | Rat | Adrenoceptors | A | pKi | 8.24 | 8.24 | 8.24 | Drug Central |
| α1B | ADA1B | Golden hamster | Adrenoceptors | A | pKi | 8.04 | 8.04 | 8.04 | Drug Central |
| α1A | ADA1A | Bovine | Adrenoceptors | A | pKi | 8.01 | 8.01 | 8.01 | Drug Central |
| α1B | ADA1B | Human | Adrenoceptors | A | pKi | 8.7 | 9.3 | 9.9 | Guide to Pharmacology |
| α1D | ADA1D | Human | Adrenoceptors | A | pKi | 8.01 | 8.01 | 8.01 | Drug Central |
| α2A | ADA2A | Human | Adrenoceptors | A | pKi | 5.3 | 5.9 | 6.5 | Guide to Pharmacology |
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
| A3 | AA3R | Human | Adenosine | A | pIC50 | 8.04 | 8.04 | 8.04 | Drug Central |
| D2 | DRD2 | Rat | Dopamine | A | pIC50 | 8.3 | 8.3 | 8.3 | Drug Central |