pramipexole


SMILES CCCN[C@H]1CCc2c(C1)sc(n2)N
InChIKey FASDKYOPVNHBLU-ZETCQYMHSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 3
Molecular weight (Da) 211.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Structure pdb 7CMU
Ligand site mutations D3

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D2 DRD2 Human Dopamine A pKi 5.1 6.25 7.4 Guide to Pharmacology
D3 DRD3 Human Dopamine A pKi 8.4 8.55 8.7 Guide to Pharmacology
D2 DRD2 Bovine Dopamine A pKd 8.8 8.8 8.8 ChEMBL
D3 DRD3 Rat Dopamine A pKi 9.11 9.19 9.35 ChEMBL
α2B ADA2B Human Adrenoceptors A pKi 7.17 7.17 7.17 ChEMBL
α2C ADA2C Human Adrenoceptors A pKi 7.28 7.28 7.28 ChEMBL
H2 HRH2 Human Histamine A pKd 7.91 7.91 7.91 ChEMBL
H2 HRH2 Human Histamine A pKi 4.86 5.21 5.57 ChEMBL
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 5.92 5.92 5.92 ChEMBL
D2 DRD2 Rat Dopamine A pKi 7.41 7.96 8.51 ChEMBL
D4 DRD4 Human Dopamine A pKi 6.86 7.99 9.31 ChEMBL
α2A ADA2A Human Adrenoceptors A pKi 7.12 7.12 7.12 ChEMBL
β2 ADRB2 Human Adrenoceptors A pKi 4.0 4.0 4.0 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 5.19 5.19 5.19 ChEMBL
D3 DRD3 Human Dopamine A pKi 7.42 8.57 9.3 ChEMBL
D3 DRD3 Human Dopamine A pKd 10.59 10.59 10.59 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 8.21 8.21 8.21 Drug Central
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 8.26 8.26 8.26 Drug Central
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 8.24 8.24 8.24 Drug Central
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 8.23 8.23 8.23 Drug Central
α2A ADA2A Human Adrenoceptors A pKi 8.15 8.15 8.15 Drug Central
α2B ADA2B Human Adrenoceptors A pKi 8.21 8.21 8.21 Drug Central
α2C ADA2C Human Adrenoceptors A pKi 8.14 8.14 8.14 Drug Central
D2 DRD2 Human Dopamine A pKi 5.2 7.0 8.41 ChEMBL
D2 DRD2 Human Dopamine A pKd 10.83 10.83 10.83 ChEMBL
D2 DRD2 Rat Dopamine A pKi 8.07 8.07 8.07 Drug Central
D2 DRD2 Bovine Dopamine A pKd 8.06 8.06 8.06 Drug Central
β2 ADRB2 Human Adrenoceptors A pKi 8.4 8.4 8.4 Drug Central
H2 HRH2 Human Histamine A pKi 8.25 8.25 8.25 Drug Central
D3 DRD3 Rat Dopamine A pKi 8.03 8.03 8.03 Drug Central
H1 HRH1 Human Histamine A pKd 8.35 8.35 8.35 ChEMBL
H4 HRH4 Human Histamine A pKd 7.8 7.8 7.8 ChEMBL
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 5.46 5.46 5.46 ChEMBL
D4 DRD4 Human Dopamine A pKi 8.03 8.03 8.03 Drug Central
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D3 DRD3 Rat Dopamine A pEC50 9.68 9.68 9.68 ChEMBL
D3 DRD3 Rat Dopamine A pIC50 8.11 8.11 8.11 ChEMBL
H2 HRH2 Human Histamine A pEC50 6.78 6.78 6.78 ChEMBL
D2 DRD2 Rat Dopamine A pEC50 7.67 8.06 8.77 ChEMBL
D2 DRD2 Rat Dopamine A pIC50 5.33 5.84 6.35 ChEMBL
D4 DRD4 Human Dopamine A pEC50 7.82 7.82 7.82 ChEMBL
α2A ADA2A Human Adrenoceptors A pEC50 5.75 5.75 5.75 ChEMBL
D3 DRD3 Human Dopamine A pEC50 8.27 8.74 9.09 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pEC50 5.93 5.93 5.93 ChEMBL
D2 DRD2 Human Dopamine A pEC50 8.18 8.18 8.18 Drug Central
D3 DRD3 Human Dopamine A pEC50 8.06 8.06 8.06 Drug Central
D2 DRD2 Human Dopamine A pEC50 6.6 7.68 8.3 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pEC50 8.23 8.23 8.23 Drug Central