PGD2


SMILES CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O
InChIKey BHMBVRSPMRCCGG-OUTUXVNYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 3
Rotatable bonds 12
Molecular weight (Da) 352.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Endogenous
Approved drug Yes

Database connections

Structure pdb 9IYB 9E9S 8ZW0

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
DP1 PD2R Human Prostanoid A pKi 7.8 8.5 9.2 Guide to Pharmacology
DP2 PD2R2 Human Prostanoid A pKi 7.6 8.1 8.6 Guide to Pharmacology
EP1 PE2R1 Human Prostanoid A pKi 4.7 4.7 4.7 Guide to Pharmacology
EP2 PE2R2 Human Prostanoid A pKi 5.0 5.0 5.0 Guide to Pharmacology
EP4 PE2R4 Human Prostanoid A pKi 8.7 8.85 9.0 Guide to Pharmacology
FP PF2R Human Prostanoid A pKi 7.7 7.7 7.7 Guide to Pharmacology
EP3 PE2R3 Rat Prostanoid A pKi 7.3950000000000005 7.4 7.4 Guide to Pharmacology
EP3 PE2R3 Mouse Prostanoid A pKi 6.55 6.55 6.55 Guide to Pharmacology
EP1 PE2R1 Rat Prostanoid A pKi 5.2 5.2 5.2 Guide to Pharmacology
FP PF2R Mouse Prostanoid A pKi 7.3 7.3 7.3 Guide to Pharmacology
DP2 PD2R2 Mouse Prostanoid A pKi 7.4 7.45 7.5 Guide to Pharmacology
EP2 PE2R2 Rat Prostanoid A pKi 5.3 5.3 5.3 Guide to Pharmacology
EP4 PE2R4 Rat Prostanoid A pKi 5.9 5.9 5.9 Guide to Pharmacology
DP1 PD2R Rat Prostanoid A pKi 7.6 7.6 7.6 Guide to Pharmacology
DP1 PD2R Mouse Prostanoid A pKi 7.7 7.7 7.7 Guide to Pharmacology
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
DP2 PD2R2 Rat Prostanoid A pIC50 8.2 8.2 8.2 Guide to Pharmacology
EP4 PE2R4 Human Prostanoid A pEC50 8.77 8.77 8.77 Guide to Pharmacology
EP3 PE2R3 Rat Prostanoid A pEC50 7.89 7.89 7.89 Guide to Pharmacology