PF-03654746


SMILES CCNC(=O)C1CC(C1)(F)c1ccc(c(c1)F)CN1CCCC1
InChIKey SXMBKHYDZOCBMT-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 5
Molecular weight (Da) 322.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Structure pdb 7F61

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H3 HRH3 Human Histamine A pKi 8.64 8.64 8.64 Guide to Pharmacology
H3 HRH3 Mouse Histamine A pKi 7.43 7.43 7.43 Guide to Pharmacology
H3 HRH3 Human Histamine A pKi 8.64 8.71 8.77 ChEMBL
H3 HRH3 Rat Histamine A pKi 7.43 7.74 8.05 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database