palupiprant


SMILES C[C@@H](C1=CC=C(C=C1)C(=O)O)NC(=O)C2=C(N(N=C2C(F)F)C)OC3=CC=CC(=C3)C(F)(F)F
InChIKey MKLKAQMPKHNQPR-NSHDSACASA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 7
Molecular weight (Da) 483.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
EP4 PE2R4 Human Prostanoid A pKi 8.2 8.2 8.2 Guide to Pharmacology
EP4 PE2R4 Human Prostanoid A pKi 8.1 8.1 8.1 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
EP4 PE2R4 Mouse Prostanoid A pIC50 6.74 6.87 7.0 ChEMBL
EP2 PE2R2 Human Prostanoid A pIC50 6.03 6.03 6.03 ChEMBL
EP4 PE2R4 Human Prostanoid A pIC50 7.6 7.95 8.35 ChEMBL