NPY-(2-36)


SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)[C@@H](C)CC
InChIKey KUMVUFICIDUBDZ-ZVYVYBDNSA-N
Sequence PSKPDNPGEDAPAEDMARYYSALRHYINLITRQRY

Chemical properties

Hydrogen bond acceptors 58
Hydrogen bond donors 58
Rotatable bonds 129
Molecular weight (Da) 4107.0

Drug properties

Molecular type Peptide
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
Y2 NPY2R Human Neuropeptide Y A pKi 8.8 8.8 8.8 Guide to Pharmacology
Y5 NPY5R Human Neuropeptide Y A pKi 8.9 8.9 8.9 Guide to Pharmacology
Y1 NPY1R Rat Neuropeptide Y A pKi 9.2 9.2 9.2 Guide to Pharmacology
Y4 NPY4R Rat Neuropeptide Y A pKi 7.9 7.9 7.9 Guide to Pharmacology
Y5 NPY5R Rat Neuropeptide Y A pKi 8.9 8.9 8.9 Guide to Pharmacology
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
Y4 NPY4R Mouse Neuropeptide Y A pIC50 5.6 6.35 7.1 Guide to Pharmacology