NPY-(13-36) (pig)


SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)[C@@H](C)CC
InChIKey BJKPGURDHQQYOX-QGTLAHJGSA-N
Sequence PAEDLARYYSALRHYINLITRQRY

Chemical properties

Hydrogen bond acceptors 40
Hydrogen bond donors 44
Rotatable bonds 95
Molecular weight (Da) 2981.6

Drug properties

Molecular type Peptide
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
Y2 NPY2R Human Neuropeptide Y A pKi 8.6 8.65 8.7 Guide to Pharmacology
Y4 NPY4R Human Neuropeptide Y A pKi 6.9 6.9 6.9 Guide to Pharmacology
Y5 NPY5R Human Neuropeptide Y A pKi 7.3 7.3 7.3 Guide to Pharmacology
Y1 NPY1R Rat Neuropeptide Y A pKi 7.8 7.8 7.8 Guide to Pharmacology
Y4 NPY4R Rat Neuropeptide Y A pKi 6.3 7.25 8.2 Guide to Pharmacology
Y5 NPY5R Rat Neuropeptide Y A pKi 7.7 7.7 7.7 Guide to Pharmacology
Y1 NPY1R Human Neuropeptide Y A pKi 6.34 6.34 6.34 ChEMBL
Y2 NPY2R Human Neuropeptide Y A pKi 9.1 9.1 9.1 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
Y2 Q9ERC0 Rat Neuropeptide Y A pIC50 7.82 7.82 7.82 ChEMBL