(-)-noradrenaline
| SMILES | NC[C@@H](c1ccc(c(c1)O)O)O |
| InChIKey | SFLSHLFXELFNJZ-QMMMGPOBSA-N |
Chemical properties
| Hydrogen bond acceptors | 4 |
| Hydrogen bond donors | 4 |
| Rotatable bonds | 2 |
| Molecular weight (Da) | 169.1 |
Drug properties
| Molecular type | Small molecule |
| Physiological/Surrogate | Endogenous |
| Approved drug | Yes |
Bioactivities
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
| α2A | ADA2A | Human | Adrenoceptors | A | pKi | 3.6 | 5.5 | 7.4 | Guide to Pharmacology |
| α1A | ADA1A | Human | Adrenoceptors | A | pKi | 4.8 | 5.6 | 6.4 | Guide to Pharmacology |
| α1B | ADA1B | Human | Adrenoceptors | A | pKi | 3.8 | 5.0 | 6.2 | Guide to Pharmacology |
| α1D | ADA1D | Human | Adrenoceptors | A | pKi | 5.5 | 6.45 | 7.4 | Guide to Pharmacology |
| α1D | ADA1D | Rat | Adrenoceptors | A | pKi | 6.3 | 6.3 | 6.3 | Guide to Pharmacology |
| α2B | ADA2B | Human | Adrenoceptors | A | pKi | 3.5 | 4.75 | 6.0 | Guide to Pharmacology |
| α2C | ADA2C | Human | Adrenoceptors | A | pKi | 4.5 | 5.65 | 6.8 | Guide to Pharmacology |
| β1 | ADRB1 | Human | Adrenoceptors | A | pKi | 5.5 | 5.75 | 6.0 | Guide to Pharmacology |
| β2 | ADRB2 | Human | Adrenoceptors | A | pKi | 4.6 | 5.0 | 5.4 | Guide to Pharmacology |
| β3 | ADRB3 | Human | Adrenoceptors | A | pKi | 4.7 | 5.5 | 6.3 | Guide to Pharmacology |
| β3 | ADRB3 | Mouse | Adrenoceptors | A | pKi | 3.8 | 3.8 | 3.8 | Guide to Pharmacology |
| β3 | ADRB3 | Rat | Adrenoceptors | A | pKi | 4.2 | 4.2 | 4.2 | Guide to Pharmacology |
| α2C | ADA2C | Mouse | Adrenoceptors | A | pKi | 6.19 | 6.19 | 6.19 | ChEMBL |
| α2A | ADA2A | Mouse | Adrenoceptors | A | pKi | 5.24 | 5.24 | 5.24 | ChEMBL |
| α2B | ADA2B | Rat | Adrenoceptors | A | pKi | 7.11 | 7.11 | 7.11 | ChEMBL |
| β2 | ADRB2 | Bovine | Adrenoceptors | A | pKi | 5.22 | 5.22 | 5.22 | ChEMBL |
| α1B | ADA1B | Golden hamster | Adrenoceptors | A | pKi | 6.58 | 6.58 | 6.58 | ChEMBL |
| β2 | ADRB2 | Rat | Adrenoceptors | A | pKi | 5.38 | 5.38 | 5.38 | ChEMBL |
| β2 | ADRB2 | Dog | Adrenoceptors | A | pKi | 4.57 | 4.94 | 5.3 | ChEMBL |
| α1A | ADA1A | Bovine | Adrenoceptors | A | pKi | 6.35 | 6.35 | 6.35 | ChEMBL |
| β1 | ADRB1 | Rat | Adrenoceptors | A | pKi | 4.58 | 5.94 | 6.9 | ChEMBL |
| β1 | B0FL73 | Guinea pig | Adrenoceptors | A | pKi | 6.4 | 6.4 | 6.4 | ChEMBL |
| α1D | ADA1D | Rat | Adrenoceptors | A | pKi | 7.65 | 7.65 | 7.65 | ChEMBL |
| α1B | ADA1B | Human | Adrenoceptors | A | pKi | 4.69 | 4.69 | 4.69 | ChEMBL |
| α1A | ADA1A | Rat | Adrenoceptors | A | pKi | 6.55 | 6.55 | 6.55 | ChEMBL |
| α1D | ADA1D | Human | Adrenoceptors | A | pKi | 5.48 | 5.93 | 6.37 | ChEMBL |
| α2B | ADA2B | Human | Adrenoceptors | A | pKi | 6.63 | 6.63 | 6.63 | ChEMBL |
| α2C | ADA2C | Human | Adrenoceptors | A | pKi | 6.41 | 6.8 | 7.2 | ChEMBL |
| β1 | ADRB1 | Human | Adrenoceptors | A | pKi | 6.38 | 6.38 | 6.38 | ChEMBL |
| α1A | ADA1A | Human | Adrenoceptors | A | pKi | 4.81 | 5.31 | 5.82 | ChEMBL |
| α2A | ADA2A | Human | Adrenoceptors | A | pKi | 5.24 | 6.21 | 7.18 | ChEMBL |
| D1 | DRD1 | Human | Dopamine | A | pKd | 4.3 | 4.3 | 4.3 | ChEMBL |
| β2 | ADRB2 | Human | Adrenoceptors | A | pKd | 5.4 | 5.4 | 5.4 | ChEMBL |
| β2 | ADRB2 | Human | Adrenoceptors | A | pKi | 4.01 | 4.75 | 5.48 | ChEMBL |
| D3 | DRD3 | Human | Dopamine | A | pKi | 6.35 | 6.35 | 6.35 | ChEMBL |
| D2 | DRD2 | Human | Dopamine | A | pKi | 5.89 | 5.89 | 5.89 | ChEMBL |
| β2 | ADRB2 | Human | Adrenoceptors | A | pKd | 8.27 | 8.27 | 8.27 | Drug Central |
| D1 | DRD1 | Human | Dopamine | A | pKd | 8.37 | 8.37 | 8.37 | Drug Central |
| α1D | ADA1D | Human | Adrenoceptors | A | pKi | 8.13 | 8.13 | 8.13 | Drug Central |
| α2A | ADA2A | Human | Adrenoceptors | A | pKi | 8.14 | 8.14 | 8.14 | Drug Central |
| α2B | ADA2B | Human | Adrenoceptors | A | pKi | 8.19 | 8.19 | 8.19 | Drug Central |
| α2C | ADA2C | Human | Adrenoceptors | A | pKi | 8.14 | 8.14 | 8.14 | Drug Central |
| β1 | ADRB1 | Human | Adrenoceptors | A | pKi | 8.22 | 8.22 | 8.22 | Drug Central |
| β3 | ADRB3 | Human | Adrenoceptors | A | pKi | 8.27 | 8.27 | 8.27 | Drug Central |
| D2 | DRD2 | Human | Dopamine | A | pKi | 8.23 | 8.23 | 8.23 | Drug Central |
| β2 | ADRB2 | Bovine | Adrenoceptors | A | pKi | 8.28 | 8.28 | 8.28 | Drug Central |
| α2B | ADA2B | Rat | Adrenoceptors | A | pKi | 8.15 | 8.15 | 8.15 | Drug Central |
| α2C | ADA2C | Mouse | Adrenoceptors | A | pKi | 8.21 | 8.21 | 8.21 | Drug Central |
| β2 | ADRB2 | Rat | Adrenoceptors | A | pKi | 8.27 | 8.27 | 8.27 | Drug Central |
| α2A | ADA2A | Mouse | Adrenoceptors | A | pKi | 8.28 | 8.28 | 8.28 | Drug Central |
| α1B | ADA1B | Golden hamster | Adrenoceptors | A | pKi | 8.18 | 8.18 | 8.18 | Drug Central |
| α1A | ADA1A | Bovine | Adrenoceptors | A | pKi | 8.2 | 8.2 | 8.2 | Drug Central |
| β1 | ADRB1 | Rat | Adrenoceptors | A | pKi | 8.16 | 8.16 | 8.16 | Drug Central |
| β2 | ADRB2 | Dog | Adrenoceptors | A | pKi | 8.28 | 8.28 | 8.28 | Drug Central |
| β1 | B0FL73 | Guinea pig | Adrenoceptors | A | pKi | 8.19 | 8.19 | 8.19 | Drug Central |
| α1A | ADA1A | Human | Adrenoceptors | A | pKi | 8.24 | 8.24 | 8.24 | Drug Central |
| α1B | ADA1B | Human | Adrenoceptors | A | pKi | 8.33 | 8.33 | 8.33 | Drug Central |
| μ | OPRM | Rat | Opioid | A | pKi | 8.31 | 8.31 | 8.31 | Drug Central |
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
| α2A | ADA2A | Human | Adrenoceptors | A | pEC50 | 6.566666666666666 | 6.57 | 6.57 | Guide to Pharmacology |
| α2A | ADA2A | Human | Adrenoceptors | A | pIC50 | 6.6 | 6.6 | 6.6 | Guide to Pharmacology |
| α1A | ADA1A | Human | Adrenoceptors | A | pEC50 | 7.7 | 8.15 | 8.6 | Guide to Pharmacology |
| α1B | ADA1B | Human | Adrenoceptors | A | pEC50 | 9.2 | 9.2 | 9.2 | Guide to Pharmacology |
| α1D | ADA1D | Human | Adrenoceptors | A | pEC50 | 7.8 | 7.8 | 7.8 | Guide to Pharmacology |
| α2B | ADA2B | Human | Adrenoceptors | A | pEC50 | 7.35 | 7.35 | 7.35 | Guide to Pharmacology |
| α2B | ADA2B | Human | Adrenoceptors | A | pIC50 | 7.8 | 7.8 | 7.8 | Guide to Pharmacology |
| α2C | ADA2C | Human | Adrenoceptors | A | pEC50 | 6.02 | 7.0 | 6.6 | Guide to Pharmacology |
| α2C | ADA2C | Human | Adrenoceptors | A | pIC50 | 6.5 | 7.55 | 8.6 | Guide to Pharmacology |
| β1 | ADRB1 | Human | Adrenoceptors | A | pEC50 | 7.9 | 7.9 | 7.9 | Guide to Pharmacology |
| β2 | ADRB2 | Human | Adrenoceptors | A | pEC50 | 6.4 | 6.4 | 6.4 | Guide to Pharmacology |
| β3 | ADRB3 | Human | Adrenoceptors | A | pEC50 | 7.2 | 7.2 | 7.2 | Guide to Pharmacology |
| β3 | ADRB3 | Rat | Adrenoceptors | A | pEC50 | 4.0 | 4.9 | 5.8 | ChEMBL |
| β1 | B0FL73 | Guinea pig | Adrenoceptors | A | pEC50 | 5.0 | 6.33 | 7.52 | ChEMBL |
| β2 | ADRB2 | Guinea pig | Adrenoceptors | A | pEC50 | 4.52 | 5.59 | 6.67 | ChEMBL |
| α1D | ADA1D | Rat | Adrenoceptors | A | pEC50 | 7.92 | 7.92 | 7.92 | ChEMBL |
| α1A | ADA1A | Rat | Adrenoceptors | A | pEC50 | 5.93 | 5.93 | 5.93 | ChEMBL |
| M1 | ACM1 | Rat | Acetylcholine (muscarinic) | A | Potency | 4.55 | 4.85 | 5.15 | ChEMBL |
| α2B | ADA2B | Human | Adrenoceptors | A | pEC50 | 6.56 | 7.05 | 7.21 | ChEMBL |
| α2C | ADA2C | Human | Adrenoceptors | A | pEC50 | 6.1 | 6.15 | 6.35 | ChEMBL |
| β3 | ADRB3 | Human | Adrenoceptors | A | pEC50 | 8.2 | 8.23 | 8.26 | ChEMBL |
| α1A | ADA1A | Human | Adrenoceptors | A | pEC50 | 5.66 | 7.25 | 8.04 | ChEMBL |
| α2A | ADA2A | Human | Adrenoceptors | A | pEC50 | 6.43 | 6.75 | 7.52 | ChEMBL |
| β2 | ADRB2 | Human | Adrenoceptors | A | pEC50 | 5.03 | 5.03 | 5.03 | ChEMBL |
| TSH | TSHR | Human | Glycoprotein hormone | A | Potency | 4.5 | 5.17 | 5.5 | ChEMBL |
| α1B | ADA1B | Rat | Adrenoceptors | A | pEC50 | 4.99 | 4.99 | 4.99 | ChEMBL |