N/OFQ-(1-13)-NH2


SMILES NCCCC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N)CCCCN)CCCN=C(N)N)C)CO)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@H]([C@H](O)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@H](Cc1ccccc1)N)C)CCCN=C(N)N
InChIKey RHMALYOXPBRJBG-CGUXNFSNSA-N
Sequence FGGFTGARKSARK

Chemical properties

Hydrogen bond acceptors 20
Hydrogen bond donors 22
Rotatable bonds 47
Molecular weight (Da) 1380.8

Drug properties

Molecular type Peptide
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
NOP OPRX Human Opioid A pKi 10.1 10.25 10.4 Guide to Pharmacology
NOP OPRX Mouse Opioid A pKi 9.04 9.07 9.1 ChEMBL
NOP OPRX Human Opioid A pKi 9.21 9.34 9.46 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
NOP OPRX Mouse Opioid A pEC50 7.94 7.95 7.96 ChEMBL
NOP OPRX Rat Opioid A pEC50 6.24 6.64 7.29 ChEMBL
NOP OPRX Human Opioid A pIC50 9.45 9.45 9.45 ChEMBL
NOP OPRX Human Opioid A pEC50 6.31 7.79 9.49 ChEMBL