nefazodone


SMILES CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl
InChIKey VRBKIVRKKCLPHA-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 7
Hydrogen bond donors 0
Rotatable bonds 10
Molecular weight (Da) 469.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 6.92 6.92 6.92 ChEMBL
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 6.58 6.58 6.58 ChEMBL
α1B ADA1B Human Adrenoceptors A pKi 6.24 6.24 6.24 ChEMBL
α1D ADA1D Human Adrenoceptors A pKi 6.35 6.35 6.35 ChEMBL
α2B ADA2B Human Adrenoceptors A pKi 6.72 6.72 6.72 ChEMBL
α2C ADA2C Human Adrenoceptors A pKi 6.45 6.45 6.45 ChEMBL
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 7.15 7.15 7.15 ChEMBL
H1 HRH1 Human Histamine A pKi 6.9 6.9 6.9 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 7.28 7.28 7.28 ChEMBL
D4 DRD4 Human Dopamine A pKi 6.49 6.49 6.49 ChEMBL
α1A ADA1A Human Adrenoceptors A pKi 6.86 6.86 6.86 ChEMBL
α2A ADA2A Human Adrenoceptors A pKi 5.86 5.86 5.86 ChEMBL
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 5.95 5.95 5.95 ChEMBL
D1 DRD1 Human Dopamine A pKi 6.15 6.15 6.15 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 6.6 6.6 6.6 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKd 6.8 6.8 6.8 ChEMBL
D3 DRD3 Human Dopamine A pKi 6.42 6.42 6.42 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 7.81 8.03 8.24 ChEMBL
D2 DRD2 Human Dopamine A pKi 6.13 6.13 6.13 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 8.15 8.15 8.15 Drug Central
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 8.1 8.1 8.1 Drug Central
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 8.15 8.15 8.15 Drug Central
α1A ADA1A Human Adrenoceptors A pKi 8.11 8.11 8.11 Drug Central
α2B ADA2B Human Adrenoceptors A pKi 8.18 8.18 8.18 Drug Central
D2 DRD2 Human Dopamine A pKi 8.17 8.17 8.17 Drug Central
H1 HRH1 Human Histamine A pKi 8.19 8.19 8.19 Drug Central
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 8.14 8.14 8.14 Drug Central
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 8.24 8.24 8.24 Guide to Pharmacology
5-HT5A 5HT5A Human 5-Hydroxytryptamine A pKi 5.96 5.96 5.96 ChEMBL
5-HT2A 5HT2A Rat 5-Hydroxytryptamine A pKi 8.09 8.09 8.09 Drug Central
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
GPR35 GPR35 Human Orphan A pIC50 5.46 5.46 5.46 ChEMBL
M2 ACM2 Human Acetylcholine (muscarinic) A pIC50 5.18 5.18 5.18 ChEMBL
NPS NPSR1 Human Neuropeptide S A Potency 4.9 4.9 4.9 ChEMBL
FPR3 FPR3 Human Formylpeptide A pIC50 5.43 5.43 5.43 ChEMBL