naloxone


SMILES C=CCN1CC[C@@]23[C@@]4([C@H]1Cc1c3c(O[C@H]2C(=O)CC4)c(cc1)O)O
InChIKey UZHSEJADLWPNLE-GRGSLBFTSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 2
Molecular weight (Da) 327.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Structure pdb 9PXU 9PXW 9PXV 9PXX 9PXY 9BJK

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
δ OPRD Human Opioid A pKi 7.2 7.2 7.2 Guide to Pharmacology
κ OPRK Human Opioid A pKi 7.6 8.1 8.6 Guide to Pharmacology
μ OPRM Human Opioid A pKi 8.9 8.9 8.9 Guide to Pharmacology
δ OPRD Mouse Opioid A pKi 7.8 7.8 7.8 Guide to Pharmacology
κ OPRK Rat Opioid A pKi 7.7 7.85 8.0 Guide to Pharmacology
μ OPRM Mouse Opioid A pKi 9.0 9.0 9.0 Guide to Pharmacology
δ OPRD Human Opioid A pKi 8.14 8.14 8.14 Drug Central
κ OPRK Human Opioid A pKi 8.07 8.07 8.07 Drug Central
μ OPRM Human Opioid A pKi 8.06 8.06 8.06 Drug Central
κ OPRK Guinea pig Opioid A pKi 8.07 8.07 8.07 Drug Central
μ OPRM Mouse Opioid A pKi 8.05 8.05 8.05 Drug Central
δ OPRD Rat Opioid A pKd 8.11 8.11 8.11 Drug Central
δ OPRD Mouse Opioid A pKd 8.14 8.14 8.14 Drug Central
μ OPRM Rat Opioid A pKd 8.03 8.03 8.03 Drug Central
κ OPRK Rat Opioid A pKd 8.05 8.05 8.05 Drug Central
CCR5 CCR5 Mouse Chemokine A pKd 8.1 8.1 8.1 Drug Central
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
δ OPRD Mouse Opioid A pIC50 6.2 6.2 6.2 Guide to Pharmacology
κ OPRK Mouse Opioid A pIC50 8.3 8.3 8.3 Guide to Pharmacology
M1 ACM1 Rat Acetylcholine (muscarinic) A Potency 5.95 5.95 5.95 ChEMBL
A3 AA3R Human Adenosine A pIC50 8.06 8.06 8.06 Drug Central
μ OPRM Bovine Opioid A pIC50 8.08 8.08 8.08 Drug Central
κ OPRK Mouse Opioid A pIC50 8.08 8.08 8.08 Drug Central