MT-II


SMILES CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1[nH]cnc1)Cc1ccccc1)CCCN=C(N)N)Cc1c[nH]c2c1cccc2)C(=O)N)NC(=O)C
InChIKey JDKLPDJLXHXHNV-MFVUMRCOSA-N
Sequence XDHFRWK

Chemical properties

Hydrogen bond acceptors 11
Hydrogen bond donors 13
Rotatable bonds 17
Molecular weight (Da) 1023.5

Drug properties

Molecular type Peptide
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
MC3 MC3R Human Melanocortin A pKi 8.3 8.3 8.3 Guide to Pharmacology
MC4 MC4R Human Melanocortin A pKi 8.2 8.5 8.8 Guide to Pharmacology
MC1 MSHR Human Melanocortin A pKi 9.88 9.93 10.0 ChEMBL
MC5 MC5R Human Melanocortin A pKi 7.4 7.4 7.4 ChEMBL
MC3 MC3R Human Melanocortin A pKi 7.73 8.18 9.03 ChEMBL
MC4 MC4R Human Melanocortin A pKi 8.9 9.31 10.47 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
MC1 MSHR Human Melanocortin A pIC50 9.4 9.4 9.4 Guide to Pharmacology
MC5 MC5R Human Melanocortin A pIC50 9.0 9.0 9.0 Guide to Pharmacology
MC5 MC5R Mouse Melanocortin A pEC50 9.24 9.78 10.17 ChEMBL
MC1 MSHR Mouse Melanocortin A pEC50 9.66 10.43 10.7 ChEMBL
MC4 MC4R Mouse Melanocortin A pEC50 9.82 10.12 10.4 ChEMBL
MC1 MSHR Human Melanocortin A pIC50 8.17 9.22 10.0 ChEMBL
MC1 MSHR Human Melanocortin A pEC50 6.96 9.23 10.2 ChEMBL
MC5 MC5R Human Melanocortin A pIC50 7.36 8.07 8.82 ChEMBL
MC5 MC5R Human Melanocortin A pEC50 7.47 8.3 8.83 ChEMBL
MC3 MC3R Human Melanocortin A pEC50 7.47 8.75 10.21 ChEMBL
MC3 MC3R Human Melanocortin A pIC50 8.01 8.63 8.92 ChEMBL
MC4 MC4R Human Melanocortin A pIC50 8.13 8.8 9.14 ChEMBL
MC4 MC4R Human Melanocortin A pEC50 8.0 8.89 10.4 ChEMBL