mepyramine


SMILES COc1ccc(cc1)CN(c1ccccn1)CCN(C)C
InChIKey YECBIJXISLIIDS-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 7
Molecular weight (Da) 285.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Structure pdb 8X63
Ligand site mutations H1

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H1 HRH1 Human Histamine A pKi 8.7 8.85 9.0 Guide to Pharmacology
H1 HRH1 Guinea pig Histamine A pKd 8.02 8.02 8.02 Drug Central
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 8.21 8.21 8.21 Drug Central
α2A ADA2A Human Adrenoceptors A pKi 8.23 8.23 8.23 Drug Central
H1 HRH1 Human Histamine A pKi 8.04 8.04 8.04 Drug Central
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 8.24 8.24 8.24 Drug Central
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 8.24 8.24 8.24 Drug Central
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
A3 AA3R Human Adenosine A pIC50 8.05 8.05 8.05 Drug Central
H1 HRH1 Rat Histamine A pIC50 8.08 8.08 8.08 Drug Central