CHEMBL264190


SMILES CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O
InChIKey DFCJPPDAOZROBS-FKWFRFQNSA-N
Sequence None

Chemical properties

Hydrogen bond acceptors 7
Hydrogen bond donors 10
Rotatable bonds 18
Molecular weight (Da) 685.3

Drug properties

Molecular type Peptide
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
MC4 MC4R Mouse Melanocortin A pKd 8.3 8.3 8.3 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
MC5 MC5R Mouse Melanocortin A pEC50 7.45 8.29 8.52 ChEMBL
MC1 MSHR Mouse Melanocortin A pEC50 6.85 7.53 7.87 ChEMBL
MC1 MSHR Mouse Melanocortin A pIC50 6.41 6.41 6.41 ChEMBL
MC4 MC4R Mouse Melanocortin A pEC50 6.62 7.89 8.64 ChEMBL
MC4 MC4R Mouse Melanocortin A pIC50 6.67 6.79 6.92 ChEMBL
MC1 MSHR Human Melanocortin A pEC50 6.64 7.79 8.37 ChEMBL
MC1 MSHR Human Melanocortin A pIC50 6.21 6.72 6.98 ChEMBL
MC5 MC5R Human Melanocortin A pEC50 8.41 8.41 8.41 ChEMBL
MC5 MC5R Human Melanocortin A pIC50 6.96 6.96 6.96 ChEMBL
MC3 MC3R Human Melanocortin A pEC50 8.15 8.15 8.15 ChEMBL
MC3 MC3R Human Melanocortin A pIC50 6.25 6.88 7.2 ChEMBL
MC4 MC4R Human Melanocortin A pIC50 5.34 6.04 6.45 ChEMBL
MC4 MC4R Human Melanocortin A pEC50 5.8 6.91 9.03 ChEMBL