VENLAFAXINE


SMILES COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1
InChIKey PNVNVHUZROJLTJ-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 5
Molecular weight (Da) 277.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 8.25 8.25 8.25 Drug Central
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 8.24 8.24 8.24 Drug Central
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 8.26 8.26 8.26 Drug Central
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
α1A ADA1A Rat Adrenoceptors A pIC50 6.85 6.95 7.05 ChEMBL
α1A ADA1A Rat Adrenoceptors A pIC50 8.15 8.15 8.15 Drug Central