leuprolide


SMILES CCNC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@H](Cc1ccc(cc1)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1)CO)CC(C)C)CC(C)C)CCCN=C(N)N
InChIKey GFIJNRVAKGFPGQ-LIJARHBVSA-N
Sequence XHWSYLLRP

Chemical properties

Hydrogen bond acceptors 14
Hydrogen bond donors 15
Rotatable bonds 32
Molecular weight (Da) 1208.6

Drug properties

Molecular type Peptide
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
GnRH1 GNRHR Human Gonadotrophin-releasing hormone A pKi 8.5 8.8 9.1 Guide to Pharmacology
LH LSHR Rat Glycoprotein hormone A pKi 9.73 9.73 9.73 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
GnRH1 GNRHR Rat Gonadotrophin-releasing hormone A pIC50 9.1 9.1 9.1 Guide to Pharmacology
GnRH1 GNRHR Human Gonadotrophin-releasing hormone A pIC50 8.02 8.02 8.02 Drug Central
GnRH1 GNRHR Human Gonadotrophin-releasing hormone A pIC50 9.1 9.42 9.54 ChEMBL
GnRH1 GNRHR Rat Gonadotrophin-releasing hormone A pIC50 8.03 8.03 8.03 Drug Central
GnRH1 GNRHR Rat Gonadotrophin-releasing hormone A pIC50 9.1 9.23 9.3 ChEMBL