CHEMBL6143437


SMILES O=C(CCOCCOCCNC(=O)c1ccc(-c2c3cc(F)c(=O)cc-3oc3cc(O)c(F)cc23)c(C(=O)O)c1)NCCOCCOCCNc1ccccc1C(=O)N1CCC(N2CCC(Cc3ccc(S(=O)(=O)c4cccc(Cl)c4)cc3)CC2)CC1
InChIKey DPHRHPMGWGUQNY-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 15
Hydrogen bond donors 5
Rotatable bonds 28
Molecular weight (Da) 1235.4

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 6.74 6.74 6.74 ChEMBL
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 7.27 7.27 7.27 ChEMBL
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 8.62 8.62 8.62 ChEMBL
M2 ACM2 Human Acetylcholine (muscarinic) A pKd 6.92 6.92 6.92 ChEMBL
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 4.25 4.25 4.25 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
M2 ACM2 Human Acetylcholine (muscarinic) A pIC50 7.39 7.39 7.39 ChEMBL