L-741,626


SMILES Clc1ccc(cc1)C1(O)CCN(CC1)Cc1c[nH]c2c1cccc2
InChIKey LLBLNMUONVVVPG-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 2
Hydrogen bond donors 2
Rotatable bonds 3
Molecular weight (Da) 340.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 6.5 6.5 6.5 Guide to Pharmacology
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 6.2 6.2 6.2 Guide to Pharmacology
D2 DRD2 Human Dopamine A pKi 7.9 8.2 8.5 Guide to Pharmacology
α2B ADA2B Human Adrenoceptors A pKi 6.22 6.22 6.22 ChEMBL
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 6.24 6.24 6.24 ChEMBL
D4 DRD4 Human Dopamine A pKi 5.82 6.14 6.66 ChEMBL
α2A ADA2A Human Adrenoceptors A pKi 5.42 5.42 5.42 ChEMBL
D1 DRD1 Human Dopamine A pKi 5.97 6.05 6.14 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 5.18 5.18 5.18 ChEMBL
D3 DRD3 Human Dopamine A pKi 6.69 6.98 7.31 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 6.05 6.11 6.16 ChEMBL
D2 DRD2 Human Dopamine A pKi 7.06 7.95 8.62 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 5.2 5.2 5.2 ChEMBL
α1A ADA1A Human Adrenoceptors A pKi 6.2 6.2 6.2 ChEMBL
μ OPRM Human Opioid A pKi 7.29 7.29 7.29 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
M1 ACM1 Rat Acetylcholine (muscarinic) A Potency 4.9 4.93 4.95 ChEMBL
D3 DRD3 Human Dopamine A pIC50 7.04 7.04 7.04 ChEMBL
D3 DRD3 Human Dopamine A pEC50 7.04 7.04 7.04 ChEMBL
D2 DRD2 Human Dopamine A pIC50 8.35 8.35 8.35 ChEMBL
D2 DRD2 Human Dopamine A pEC50 8.35 8.35 8.35 ChEMBL
TSH TSHR Human Glycoprotein hormone A Potency 5.5 5.5 5.5 ChEMBL