JP1302


SMILES CN1CCN(CC1)c1ccc(cc1)Nc1c2ccccc2nc2c1cccc2
InChIKey QZKGUNQLVFEEBA-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 3
Molecular weight (Da) 368.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 5.79 5.79 5.79 ChEMBL
α1B ADA1B Human Adrenoceptors A pKi 5.57 5.57 5.57 ChEMBL
α1D ADA1D Human Adrenoceptors A pKi 5.76 5.76 5.76 ChEMBL
α2B ADA2B Human Adrenoceptors A pKi 5.76 5.79 5.82 ChEMBL
α2C ADA2C Human Adrenoceptors A pKi 7.4 7.5 7.55 ChEMBL
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 6.38 6.38 6.38 ChEMBL
H1 HRH1 Human Histamine A pKi 6.39 6.39 6.39 ChEMBL
α1A ADA1A Human Adrenoceptors A pKi 5.8 5.8 5.8 ChEMBL
α2A ADA2A Human Adrenoceptors A pKi 5.5 5.57 5.64 ChEMBL
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 6.42 6.42 6.42 ChEMBL
H3 HRH3 Human Histamine A pKi 7.08 7.08 7.08 ChEMBL
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 6.69 6.69 6.69 ChEMBL
β2 ADRB2 Human Adrenoceptors A pKi 6.09 6.09 6.09 ChEMBL
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 6.14 6.14 6.14 ChEMBL
D1 DRD1 Human Dopamine A pKi 5.34 5.34 5.34 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
α2C ADA2C Human Adrenoceptors A pKB 6.9 7.35 7.8 Guide to Pharmacology
apelin APJ Human Apelin A pIC50 5.45 5.45 5.45 ChEMBL