JNJ-5207787


SMILES N#Cc1cccc(c1)/C=C/C(=O)N(c1ccc2c(c1)N(CC2)C(=O)C)C1CCN(CC1)CCC1CCCC1
InChIKey DSEJCLDJIFTPPH-FMIVXFBMSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 7
Molecular weight (Da) 510.3

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 5.82 5.82 5.82 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 5.36 5.36 5.36 ChEMBL
β3 ADRB3 Human Adrenoceptors A pKi 5.02 5.02 5.02 ChEMBL
D3 DRD3 Human Dopamine A pKi 5.79 5.79 5.79 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
Y2 NPY2R Human Neuropeptide Y A pIC50 6.9 7.0 7.1 Guide to Pharmacology
Y2 NPY2R Human Neuropeptide Y A pIC50 7.0 7.07 7.2 ChEMBL