LATREPIRDINE


SMILES Cc1ccc2c(c1)c1c(n2CCc2ccc(C)nc2)CCN(C)C1
InChIKey JNODQFNWMXFMEV-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 3
Molecular weight (Da) 319.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT6 5HT6R Rat 5-Hydroxytryptamine A pKi 6.92 6.92 6.92 ChEMBL
5-HT1E 5HT1E Human 5-Hydroxytryptamine A pKi 5.25 5.25 5.25 ChEMBL
5-HT5A 5HT5A Human 5-Hydroxytryptamine A pKi 6.97 6.97 6.97 ChEMBL
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 6.38 6.38 6.38 ChEMBL
α1D ADA1D Human Adrenoceptors A pKi 6.12 6.12 6.12 ChEMBL
α2B ADA2B Human Adrenoceptors A pKi 7.34 7.34 7.34 ChEMBL
H2 HRH2 Human Histamine A pKi 6.67 6.67 6.67 ChEMBL
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 7.83 8.03 8.1 ChEMBL
α1A ADA1A Human Adrenoceptors A pKi 6.38 6.8 7.22 ChEMBL
α2A ADA2A Human Adrenoceptors A pKi 6.14 6.55 6.96 ChEMBL
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 6.84 7.4 7.58 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 6.22 6.22 6.22 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 7.12 7.12 7.12 ChEMBL
D3 DRD3 Human Dopamine A pKi 6.34 6.34 6.34 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 6.14 6.67 7.21 ChEMBL
D2 DRD2 Human Dopamine A pKi 5.81 6.0 6.2 ChEMBL
α1B ADA1B Human Adrenoceptors A pKi 5.88 5.88 5.88 ChEMBL
α2C ADA2C Human Adrenoceptors A pKi 5.53 5.53 5.53 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H1 HRH1 Human Histamine A pIC50 5.8 6.3 6.8 ChEMBL
5-HT6 5HT6R Human 5-Hydroxytryptamine A pIC50 5.94 6.01 6.05 ChEMBL