(R)-SCH-23390


SMILES CN1CCC2=CC(=C(C=C2[C@H](C1)C3=CC=CC=C3)O)Cl
InChIKey GOTMKOSCLKVOGG-OAHLLOKOSA-N

Chemical properties

Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 1
Molecular weight (Da) 287.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Ligand site mutations D1 D2 D5

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D1 DRD1 Human Dopamine A pKi 7.4 8.72 9.5 Guide to Pharmacology
D2 DRD2 Human Dopamine A pKi 5.3 5.3 5.3 Guide to Pharmacology
D5 DRD5 Human Dopamine A pKi 7.5 8.5 9.5 Guide to Pharmacology
D1 DRD1 Mouse Dopamine A pKi 9.4 9.4 9.4 ChEMBL
D1 DRD1 Goldfish Dopamine A pKi 8.89 8.89 8.89 ChEMBL
D1 DRD1 Bovine Dopamine A pKi 7.43 8.75 10.0 ChEMBL
D3 DRD3 Rat Dopamine A pKi 6.12 6.12 6.12 ChEMBL
D5 DRD5 Human Dopamine A pKi 8.09 9.05 9.77 ChEMBL
D1 DRD1 Rat Dopamine A pKi 6.17 9.19 9.92 ChEMBL
D2 DRD2 Rat Dopamine A pKi 6.05 6.52 9.27 ChEMBL
D1 DRD1 Human Dopamine A pKi 6.72 9.26 10.0 ChEMBL
D1 DRD1 Human Dopamine A pKd 9.42 9.42 9.42 ChEMBL
D2 DRD2 Human Dopamine A pKi 6.0 6.58 7.7 ChEMBL
5-HT2C 5HT2C Rat 5-Hydroxytryptamine A pKi 7.9 7.9 7.9 ChEMBL
D2 DRD2 Mouse Dopamine A pKi 5.92 5.92 5.92 ChEMBL
D1 DRD1 Pig Dopamine A pKi 9.3 9.3 9.3 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
GPR183 GP183 Human Orphan A pEC50 5.31 5.31 5.31 ChEMBL
CX3CR1 CX3C1 Human Chemokine A pEC50 5.42 5.42 5.42 ChEMBL
D5 DRD5 Human Dopamine A pIC50 8.96 9.4 9.82 ChEMBL
D1 DRD1 Rat Dopamine A pIC50 8.37 8.9 9.24 ChEMBL
M1 ACM1 Rat Acetylcholine (muscarinic) A Potency 5.4 5.4 5.4 ChEMBL
GPR119 GP119 Human GPR18, GPR55 and GPR119 A pEC50 5.22 5.22 5.22 ChEMBL
FFA4 FFAR4 Human Free fatty acid A pEC50 5.31 5.31 5.31 ChEMBL
D2 DRD2 Rat Dopamine A pIC50 5.72 5.97 6.22 ChEMBL
D1 DRD1 Human Dopamine A pIC50 6.28 8.58 9.66 ChEMBL
β2 ADRB2 Human Adrenoceptors A pEC50 5.34 5.34 5.34 ChEMBL
TSH TSHR Human Glycoprotein hormone A Potency 4.6 4.9 5.5 ChEMBL
D2 DRD2 Human Dopamine A pIC50 5.69 6.93 7.59 ChEMBL
GLP-1 GLP1R Human Glucagon B1 pEC50 5.29 5.29 5.29 ChEMBL
apelin APJ Human Apelin A pEC50 5.18 5.18 5.18 ChEMBL