INCB3344


SMILES CCO[C@H]1CN(C[C@@H]1NC(=O)CNC(=O)c1cccc(c1)C(F)(F)F)[C@@H]1CC[C@](CC1)(O)c1ccc2c(c1)OCO2
InChIKey MZEOSVPWMSEFPW-UTWBDPIXSA-N

Chemical properties

Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 8
Molecular weight (Da) 577.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
CCR2 CCR2 Human Chemokine A pKd 8.92 9.19 9.64 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
CCR2 CCR2 Mouse Chemokine A pIC50 8.0 8.0 8.0 Guide to Pharmacology
CCR2 CCR2 Rat Chemokine A pIC50 5.14 5.14 5.14 ChEMBL
CCR2 CCR2 Human Chemokine A pIC50 8.29 8.36 8.42 ChEMBL
CCR2 CCR2 Mouse Chemokine A pIC50 8.02 8.06 8.11 ChEMBL