idazoxan


SMILES C1CN=C(N1)C2COC3=CC=CC=C3O2
InChIKey HPMRFMKYPGXPEP-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 1
Molecular weight (Da) 204.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Ligand site mutations α2A

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
α2A ADA2A Human Adrenoceptors A pKi 7.2 7.6 8.0 Guide to Pharmacology
α2B ADA2B Human Adrenoceptors A pKi 6.4 7.0 7.6 Guide to Pharmacology
α2C ADA2C Human Adrenoceptors A pKi 6.6 7.15 7.7 Guide to Pharmacology
α2B ADA2B Human Adrenoceptors A pKi 7.0 7.43 7.64 ChEMBL
α2C ADA2C Human Adrenoceptors A pKi 7.72 7.74 7.75 ChEMBL
α2A ADA2A Human Adrenoceptors A pKi 8.1 8.13 8.15 ChEMBL
α2A ADA2A Bovine Adrenoceptors A pKi 8.82 8.82 8.82 ChEMBL
α1A ADA1A Bovine Adrenoceptors A pKi 6.3 6.3 6.3 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
α2B ADA2B Human Adrenoceptors A pIC50 7.71 7.71 7.71 ChEMBL
α2C ADA2C Human Adrenoceptors A pIC50 7.27 7.27 7.27 ChEMBL
α1A ADA1A Human Adrenoceptors A pIC50 5.54 5.54 5.54 ChEMBL
α2A ADA2A Human Adrenoceptors A pIC50 8.08 8.08 8.08 ChEMBL
NPS NPSR1 Human Neuropeptide S A Potency 5.0 5.0 5.0 ChEMBL