ACRIVASTINE


SMILES Cc1ccc(/C(=C\CN2CCCC2)c2cccc(/C=C/C(=O)O)n2)cc1
InChIKey PWACSDKDOHSSQD-IUTFFREVSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 6
Molecular weight (Da) 348.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Ligand site mutations H1

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H1 HRH1 Human Histamine A pKi 7.7 7.7 7.7 ChEMBL
H1 HRH1 Human Histamine A pKd 6.9 6.9 6.9 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H1 HRH1 Human Histamine A pIC50 8.15 8.15 8.15 Drug Central
H1 HRH1 Guinea pig Histamine A pIC50 8.28 8.28 8.28 Drug Central
H1 HRH1 Guinea pig Histamine A pIC50 5.21 5.21 5.21 ChEMBL