GW803430


SMILES COc1cc(ccc1OCCN1CCCC1)n1cnc2c(c1=O)sc(c2)c1ccc(cc1)Cl
InChIKey MWULMTACIBZPGN-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 7
Hydrogen bond donors 0
Rotatable bonds 7
Molecular weight (Da) 481.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
MCH1 MCHR1 Rat Melanin-concentrating hormone A pKi 9.47 9.47 9.47 ChEMBL
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 5.45 5.45 5.45 ChEMBL
α1D ADA1D Human Adrenoceptors A pKi 5.22 5.22 5.22 ChEMBL
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 5.58 5.58 5.58 ChEMBL
MCH1 MCHR1 Human Melanin-concentrating hormone A pKi 8.55 8.61 8.66 ChEMBL
α2A ADA2A Human Adrenoceptors A pKi 5.53 5.53 5.53 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 6.05 6.05 6.05 ChEMBL
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 5.91 5.91 5.91 ChEMBL
D3 DRD3 Human Dopamine A pKi 6.12 6.12 6.12 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 6.28 6.28 6.28 ChEMBL
5-HT5A 5HT5A Human 5-Hydroxytryptamine A pKi 6.25 6.25 6.25 ChEMBL
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 5.38 5.38 5.38 ChEMBL
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 5.77 5.77 5.77 ChEMBL
H3 HRH3 Human Histamine A pKi 6.68 6.68 6.68 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
MCH1 MCHR1 Human Melanin-concentrating hormone A pIC50 9.3 9.3 9.3 Guide to Pharmacology
MCH1 MCHR1 Human Melanin-concentrating hormone A pIC50 7.05 8.36 9.3 ChEMBL