guanabenz
| SMILES | NC(=N/N=C\c1c(Cl)cccc1Cl)N |
| InChIKey | WDZVGELJXXEGPV-PQMHYQBVSA-N |
Chemical properties
| Hydrogen bond acceptors | 2 |
| Hydrogen bond donors | 2 |
| Rotatable bonds | 2 |
| Molecular weight (Da) | 230.0 |
Drug properties
| Molecular type | Small molecule |
| Physiological/Surrogate | Surrogate |
| Approved drug | Yes |
Database connections
Bioactivities
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
| α2C | ADA2C | Human | Adrenoceptors | A | pKd | 6.4 | 6.4 | 6.4 | Guide to Pharmacology |
| α2A | ADA2A | Human | Adrenoceptors | A | pKi | 7.0 | 7.35 | 7.7 | Guide to Pharmacology |
| α2B | ADA2B | Human | Adrenoceptors | A | pKi | 6.0 | 6.0 | 6.0 | Guide to Pharmacology |
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
| α2C | ADA2C | Human | Adrenoceptors | A | pEC50 | 5.14 | 7.13 | 6.57 | Guide to Pharmacology |
| α2C | ADA2C | Human | Adrenoceptors | A | pIC50 | 6.0 | 6.95 | 7.9 | Guide to Pharmacology |
| α2A | ADA2A | Human | Adrenoceptors | A | pEC50 | 8.7 | 8.7 | 8.7 | Guide to Pharmacology |
| α2A | ADA2A | Human | Adrenoceptors | A | pIC50 | 7.4 | 7.65 | 8.4 | Guide to Pharmacology |
| α2B | ADA2B | Human | Adrenoceptors | A | pEC50 | 8.2 | 8.2 | 8.2 | Guide to Pharmacology |
| α2B | ADA2B | Human | Adrenoceptors | A | pIC50 | 9.0 | 9.0 | 9.0 | Guide to Pharmacology |