BRILAROXAZINE


SMILES O=C1COc2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc2N1
InChIKey PMKMNTBZJOXTJW-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 7
Molecular weight (Da) 449.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 7.29 7.29 7.29 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 9.72 9.72 9.72 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 8.82 8.82 8.82 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 7.23 7.69 8.6 ChEMBL
D2 DRD2 Human Dopamine A pKi 9.21 9.21 9.21 ChEMBL
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 8.57 8.57 8.57 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pIC50 8.65 8.65 8.65 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pIC50 6.89 6.89 6.89 ChEMBL
D2 DRD2 Human Dopamine A pIC50 8.71 8.71 8.71 ChEMBL