GLPG1205


SMILES O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1c2ccc(c1)C#CC1CC1
InChIKey IRBAWVGZNJIROV-SFHVURJKSA-N

Chemical properties

Hydrogen bond acceptors 6
Hydrogen bond donors 0
Rotatable bonds 3
Molecular weight (Da) 378.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Structure pdb 9WIJ

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
GPR84 GPR84 Human Orphan A pKi 7.52 7.52 7.52 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
GPR84 GPR84 Human Orphan A pIC50 7.0 9.0 11.0 Guide to Pharmacology
GPR84 GPR84 Human Orphan A pIC50 6.7 8.16 11.0 ChEMBL
GPR84 GPR84 Human Orphan A pEC50 4.03 5.39 7.27 ChEMBL
GPR84 GPR84 Mouse Orphan A pIC50 5.78 5.78 5.78 ChEMBL