galanin(2-29) (rat/mouse)


SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)[C@@H](C)O)C(C)C)C(=O)N[C@H](C(=O)O)[C@@H](C)O
InChIKey ZXUSESRUZIGRGN-UGPLCUGJSA-N
Sequence WTLNSAGYLLGPHAVGNHRSFSDKNGLT

Chemical properties

Hydrogen bond acceptors 43
Hydrogen bond donors 44
Rotatable bonds 94
Molecular weight (Da) 3011.5

Drug properties

Molecular type Peptide
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
GAL2 GALR2 Human Galanin A pKi 9.04 9.04 9.04 Guide to Pharmacology
GAL3 GALR3 Rat Galanin A pKi 7.9 7.9 7.9 Guide to Pharmacology
GAL2 GALR2 Rat Galanin A pKi 7.25 7.99 8.72 Guide to Pharmacology
GAL1 GALR1 Rat Galanin A pKi 5.96 6.52 7.07 Guide to Pharmacology
GAL2 GALR2 Mouse Galanin A pKi 8.17 8.17 8.17 Guide to Pharmacology
GAL1 GALR1 Mouse Galanin A pKi 7.07 7.52 7.97 Guide to Pharmacology
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
GAL2 GALR2 Rat Galanin A pIC50 8.54 8.54 8.54 Guide to Pharmacology
GAL1 GALR1 Rat Galanin A pIC50 8.14 8.14 8.14 Guide to Pharmacology
GAL1 GALR1 Human Galanin A pIC50 8.0 8.0 8.0 Guide to Pharmacology