frovatriptan


SMILES CN[C@H]1Cc2c(CC1)[nH]c1c2cc(cc1)C(=N)O
InChIKey XPSQPHWEGNHMSK-SECBINFHSA-N

Chemical properties

Hydrogen bond acceptors 2
Hydrogen bond donors 4
Rotatable bonds 2
Molecular weight (Da) 243.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 7.22 7.22 7.22 Guide to Pharmacology
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 7.99 7.99 7.99 Guide to Pharmacology
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 8.36 8.36 8.36 Guide to Pharmacology
5-HT1E 5HT1E Human 5-Hydroxytryptamine A pKi 6.51 6.51 6.51 ChEMBL
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 8.36 8.36 8.36 ChEMBL
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 7.64 8.0 8.36 ChEMBL
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 7.44 7.44 7.44 ChEMBL
D4 DRD4 Human Dopamine A pKi 6.04 6.04 6.04 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 5.83 6.52 7.21 ChEMBL
D2 DRD2 Human Dopamine A pKi 6.16 6.16 6.16 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 8.14 8.14 8.14 Drug Central
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 8.1 8.1 8.1 Drug Central
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 8.08 8.08 8.08 Drug Central
μ OPRM Human Opioid A pKi 6.73 6.73 6.73 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database