CHEMBL4448933


SMILES Nc1ccccc1C(=O)N1CCC(N2CCC(Cc3ccc(S(=O)(=O)c4cccc(Cl)c4)cc3)CC2)CC1
InChIKey WIEMOFKMOGPXQF-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 6
Molecular weight (Da) 551.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 6.92 7.03 7.14 ChEMBL
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 7.04 7.54 8.03 ChEMBL
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 6.17 6.44 6.71 ChEMBL
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 8.96 9.52 9.7 ChEMBL
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 6.37 6.43 6.49 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
M2 ACM2 Human Acetylcholine (muscarinic) A pIC50 7.1 7.1 7.1 ChEMBL