endomorphin-1 (Human)


SMILES Oc1ccc(cc1)C[C@@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N)Cc1ccccc1)Cc1c[nH]c2c1cccc2)N
InChIKey ZEXLJFNSKAHNFH-SYKYGTKKSA-N
Sequence YPWF

Chemical properties

Hydrogen bond acceptors 6
Hydrogen bond donors 6
Rotatable bonds 12
Molecular weight (Da) 610.3

Drug properties

Molecular type Peptide
Physiological/Surrogate Endogenous
Approved drug No

Database connections

Structure pdb 8F7R 9WSX 9WSW

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
δ OPRD Human Opioid A pKi 6.1 6.1 6.1 Guide to Pharmacology
μ OPRM Human Opioid A pKi 8.3 8.3 8.3 Guide to Pharmacology
κ OPRK Rat Opioid A pKi 7.28 7.28 7.28 ChEMBL
δ OPRD Rat Opioid A pKi 5.19 5.61 6.24 ChEMBL
μ OPRM Rat Opioid A pKi 7.75 8.67 9.8 ChEMBL
δ OPRD Human Opioid A pKi 5.22 5.37 5.56 ChEMBL
μ OPRM Human Opioid A pKi 8.34 8.82 9.54 ChEMBL
κ OPRK Guinea pig Opioid A pKi 5.29 5.46 5.63 ChEMBL
κ OPRK Human Opioid A pKi 5.69 5.69 5.69 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
μ OPRM Mouse Opioid A pIC50 7.44 7.44 7.44 ChEMBL
δ OPRD Mouse Opioid A pIC50 6.55 7.31 7.58 ChEMBL
δ OPRD Rat Opioid A pIC50 5.45 5.45 5.45 ChEMBL
μ OPRM Rat Opioid A pIC50 7.25 8.79 9.37 ChEMBL
μ OPRM Rat Opioid A pEC50 6.78 6.88 6.98 ChEMBL
δ OPRD Human Opioid A pEC50 6.03 6.03 6.03 ChEMBL
μ OPRM Human Opioid A pIC50 7.18 7.84 8.49 ChEMBL
μ OPRM Human Opioid A pEC50 7.21 7.68 7.85 ChEMBL