5-(N,N-hexamethylene)-amiloride


SMILES NC(=NC(=O)c1nc(Cl)c(nc1N)N1CCCCCC1)N
InChIKey RQQJJXVETXFINY-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 2
Molecular weight (Da) 311.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Ligand site mutations A2A A3

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
α2A ADA2A Human Adrenoceptors A pKd 2.5 2.5 2.5 Guide to Pharmacology
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
GnRH1 GNRHR Human Gonadotrophin-releasing hormone A pIC50 4.3 4.3 4.3 Guide to Pharmacology
TSH TSHR Human Glycoprotein hormone A Potency 4.8 4.8 4.8 ChEMBL
M1 ACM1 Rat Acetylcholine (muscarinic) A Potency 4.75 4.75 4.75 ChEMBL
A2A AA2AR Human Adenosine A pIC50 5.29 5.29 5.29 ChEMBL