d(CH2)5[Tyr(Et)2,Val4,des-Gly9]AVP


SMILES CCOc1ccc(cc1)C[C@H]1NC(=O)CC2(CCCCC2)SSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)Cc1ccccc1)C(C)C)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N)CCCN=C(N)N
InChIKey DRLYXDZRLDZVIS-XXNQTUAPSA-N
Sequence CYFVNCPR

Chemical properties

Hydrogen bond acceptors 13
Hydrogen bond donors 10
Rotatable bonds 17
Molecular weight (Da) 1078.5

Drug properties

Molecular type Peptide
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
V1A V1AR Human Vasopressin and oxytocin A pKi 9.1 9.1 9.1 Guide to Pharmacology
V1B V1BR Human Vasopressin and oxytocin A pKi 5.7 5.7 5.7 Guide to Pharmacology
V2 V2R Human Vasopressin and oxytocin A pKi 8.0 8.15 8.3 Guide to Pharmacology
V2 V2R Human Vasopressin and oxytocin A pKi 8.96 8.96 8.96 ChEMBL
V2 V2R Pig Vasopressin and oxytocin A pKi 7.92 8.29 8.41 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database