CHEMBL38182


SMILES N#Cc1ccc(NC(=O)Nc2ccccc2Br)c2nn[nH]c12
InChIKey SEDUMQWZEOMXSO-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 3
Rotatable bonds 2
Molecular weight (Da) 356.0

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Ligand site mutations CXCR2

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
CXCR2 CXCR2 Human Chemokine A pKd 7.0 7.75 8.5 ChEMBL
CXCR2 CXCR2 Human Chemokine A pKi 8.68 8.68 8.68 ChEMBL
β3 ADRB3 Human Adrenoceptors A pKi 5.06 5.06 5.06 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
CXCR2 CXCR2 Human Chemokine A pIC50 6.55 7.09 8.0 ChEMBL