4-DAMP
| SMILES | O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C |
| InChIKey | HYJRTXSYDAFGJK-UHFFFAOYSA-N |
Chemical properties
| Hydrogen bond acceptors | 2 |
| Hydrogen bond donors | 0 |
| Rotatable bonds | 4 |
| Molecular weight (Da) | 324.2 |
Drug properties
| Molecular type | Small molecule |
| Physiological/Surrogate | Surrogate |
| Approved drug | No |
Bioactivities
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
| M1 | ACM1 | Human | Acetylcholine (muscarinic) | A | pKi | 9.3 | 9.3 | 9.3 | Guide to Pharmacology |
| M3 | ACM3 | Human | Acetylcholine (muscarinic) | A | pKi | 9.3 | 9.3 | 9.3 | Guide to Pharmacology |
| M4 | ACM4 | Human | Acetylcholine (muscarinic) | A | pKi | 8.9 | 8.9 | 8.9 | Guide to Pharmacology |
| M5 | ACM5 | Human | Acetylcholine (muscarinic) | A | pKi | 9.0 | 9.0 | 9.0 | Guide to Pharmacology |
| M4 | ACM4 | Rat | Acetylcholine (muscarinic) | A | pKi | 9.1 | 9.1 | 9.1 | Guide to Pharmacology |
| M2 | ACM2 | Rat | Acetylcholine (muscarinic) | A | pKi | 8.2 | 8.2 | 8.2 | Guide to Pharmacology |
| M5 | ACM5 | Rat | Acetylcholine (muscarinic) | A | pKi | 8.9 | 8.9 | 8.9 | Guide to Pharmacology |
| M1 | ACM1 | Rat | Acetylcholine (muscarinic) | A | pKi | 8.9 | 8.9 | 8.9 | Guide to Pharmacology |
| M3 | ACM3 | Rat | Acetylcholine (muscarinic) | A | pKi | 9.2 | 9.2 | 9.2 | Guide to Pharmacology |
| M1 | ACM1 | Rat | Acetylcholine (muscarinic) | A | pKi | 9.23 | 9.23 | 9.23 | ChEMBL |
| M5 | ACM5 | Human | Acetylcholine (muscarinic) | A | pKi | 9.32 | 9.45 | 9.66 | ChEMBL |
| M4 | ACM4 | Human | Acetylcholine (muscarinic) | A | pKi | 9.06 | 9.24 | 9.43 | ChEMBL |
| M3 | ACM3 | Human | Acetylcholine (muscarinic) | A | pKi | 8.6 | 9.3 | 9.66 | ChEMBL |
| M2 | ACM2 | Human | Acetylcholine (muscarinic) | A | pKd | 8.57 | 8.57 | 8.57 | ChEMBL |
| M2 | ACM2 | Human | Acetylcholine (muscarinic) | A | pKi | 7.64 | 7.64 | 7.64 | ChEMBL |
| M1 | ACM1 | Human | Acetylcholine (muscarinic) | A | pKi | 8.96 | 8.96 | 8.96 | ChEMBL |
| M2 | ACM2 | Human | Acetylcholine (muscarinic) | A | pKi | 8.4 | 8.4 | 8.4 | Guide to Pharmacology |
| M4 | ACM4 | Rat | Acetylcholine (muscarinic) | A | pKi | 9.29 | 9.29 | 9.29 | ChEMBL |
| M2 | ACM2 | Rat | Acetylcholine (muscarinic) | A | pKi | 8.4 | 8.4 | 8.4 | ChEMBL |
| M3 | ACM3 | Rat | Acetylcholine (muscarinic) | A | pKi | 8.94 | 8.94 | 8.94 | ChEMBL |
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
| M1 | ACM1 | Rat | Acetylcholine (muscarinic) | A | Potency | 7.8 | 7.88 | 7.95 | ChEMBL |
| M5 | ACM5 | Human | Acetylcholine (muscarinic) | A | pIC50 | 9.08 | 9.3 | 9.49 | ChEMBL |
| M4 | ACM4 | Human | Acetylcholine (muscarinic) | A | pIC50 | 8.72 | 9.1 | 9.31 | ChEMBL |
| M3 | ACM3 | Human | Acetylcholine (muscarinic) | A | pIC50 | 8.29 | 9.09 | 9.51 | ChEMBL |
| M2 | ACM2 | Human | Acetylcholine (muscarinic) | A | pIC50 | 7.26 | 7.26 | 7.26 | ChEMBL |
| M1 | ACM1 | Human | Acetylcholine (muscarinic) | A | pIC50 | 8.35 | 8.35 | 8.35 | ChEMBL |