TALIPEXOLE


SMILES C=CCN1CCc2nc(N)sc2CC1
InChIKey DHSSDEDRBUKTQY-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 2
Molecular weight (Da) 209.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Ligand site mutations α2A

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D2 DRD2 Rat Dopamine A pKi 5.57 6.91 8.24 ChEMBL
D3 DRD3 Human Dopamine A pKi 7.17 7.17 7.17 ChEMBL
α2C ADA2C Human Adrenoceptors A pKi 8.17 8.17 8.17 Drug Central
D2 DRD2 Human Dopamine A pKi 8.2 8.2 8.2 Drug Central
D3 DRD3 Human Dopamine A pKi 8.13 8.13 8.13 Drug Central
D4 DRD4 Human Dopamine A pKi 8.19 8.19 8.19 Drug Central
D5 DRD5 Human Dopamine A pKi 8.26 8.26 8.26 Drug Central
D2 DRD2 Human Dopamine A pKi 6.21 6.21 6.21 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 8.24 8.24 8.24 Drug Central
α1B ADA1B Human Adrenoceptors A pKi 8.27 8.27 8.27 Drug Central
α1D ADA1D Human Adrenoceptors A pKi 8.23 8.23 8.23 Drug Central
α2A ADA2A Human Adrenoceptors A pKi 8.16 8.16 8.16 Drug Central
α2B ADA2B Human Adrenoceptors A pKi 8.17 8.17 8.17 Drug Central
D2 DRD2 Rat Dopamine A pKi 8.08 8.08 8.08 Drug Central
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database