clonidine
| SMILES | Clc1cccc(c1NC1=NCCN1)Cl |
| InChIKey | GJSURZIOUXUGAL-UHFFFAOYSA-N |
Chemical properties
| Hydrogen bond acceptors | 3 |
| Hydrogen bond donors | 2 |
| Rotatable bonds | 1 |
| Molecular weight (Da) | 229.0 |
Drug properties
| Molecular type | Small molecule |
| Physiological/Surrogate | Surrogate |
| Approved drug | Yes |
Bioactivities
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
| α1D | ADA1D | Human | Adrenoceptors | A | pKi | 5.6 | 5.6 | 5.6 | Guide to Pharmacology |
| α2A | ADA2A | Human | Adrenoceptors | A | pKi | 6.7 | 7.95 | 9.2 | Guide to Pharmacology |
| α2B | ADA2B | Human | Adrenoceptors | A | pKi | 6.3 | 7.9 | 9.5 | Guide to Pharmacology |
| α2C | ADA2C | Human | Adrenoceptors | A | pKi | 6.0 | 6.9 | 7.8 | Guide to Pharmacology |
| α1D | ADA1D | Rat | Adrenoceptors | A | pKi | 6.9 | 6.9 | 6.9 | Guide to Pharmacology |
| 5-HT1A | 5HT1A | Human | 5-Hydroxytryptamine | A | pKi | 8.26 | 8.26 | 8.26 | Drug Central |
| α1A | ADA1A | Human | Adrenoceptors | A | pKi | 8.19 | 8.19 | 8.19 | Drug Central |
| α1B | ADA1B | Human | Adrenoceptors | A | pKi | 8.19 | 8.19 | 8.19 | Drug Central |
| α1D | ADA1D | Human | Adrenoceptors | A | pKi | 8.21 | 8.21 | 8.21 | Drug Central |
| α2A | ADA2A | Human | Adrenoceptors | A | pKi | 8.07 | 8.07 | 8.07 | Drug Central |
| α2B | ADA2B | Human | Adrenoceptors | A | pKi | 8.12 | 8.12 | 8.12 | Drug Central |
| α1D | ADA1D | Rat | Adrenoceptors | A | pKi | 8.16 | 8.16 | 8.16 | Drug Central |
| α1B | ADA1B | Rat | Adrenoceptors | A | pKi | 8.22 | 8.22 | 8.22 | Drug Central |
| α2A | ADA2A | Rat | Adrenoceptors | A | pKi | 8.03 | 8.03 | 8.03 | Drug Central |
| α1A | ADA1A | Rat | Adrenoceptors | A | pKd | 8.18 | 8.18 | 8.18 | Drug Central |
| β1 | B0FL73 | Guinea pig | Adrenoceptors | A | pKd | 8.36 | 8.36 | 8.36 | Drug Central |
| α2B | ADA2B | Rat | Adrenoceptors | A | pKi | 8.09 | 8.09 | 8.09 | Drug Central |
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
| α2A | ADA2A | Human | Adrenoceptors | A | pEC50 | 7.666666666666667 | 7.67 | 7.67 | Guide to Pharmacology |
| α2A | ADA2A | Human | Adrenoceptors | A | pIC50 | 8.2 | 8.2 | 8.2 | Guide to Pharmacology |
| α2B | ADA2B | Human | Adrenoceptors | A | pEC50 | 7.7 | 7.7 | 7.7 | Guide to Pharmacology |
| α2B | ADA2B | Human | Adrenoceptors | A | pIC50 | 8.6 | 8.6 | 8.6 | Guide to Pharmacology |
| α2C | ADA2C | Human | Adrenoceptors | A | pEC50 | 4.64 | 6.75 | 6.74 | Guide to Pharmacology |
| α2C | ADA2C | Human | Adrenoceptors | A | pIC50 | 7.5 | 7.6 | 7.7 | Guide to Pharmacology |
| α2C | ADA2C | Human | Adrenoceptors | A | pEC50 | 8.17 | 8.17 | 8.17 | Drug Central |
| α1A | ADA1A | Bovine | Adrenoceptors | A | pEC50 | 8.15 | 8.15 | 8.15 | Drug Central |
| 5-HT1A | 5HT1A | Rat | 5-Hydroxytryptamine | A | pIC50 | 8.28 | 8.28 | 8.28 | Drug Central |
| α2A | ADA2A | Bovine | Adrenoceptors | A | pIC50 | 8.06 | 8.06 | 8.06 | Drug Central |