CHEMBL259656


SMILES O=C(c1cc2c(cc1F)OC(c1ccc(F)cc1)(c1ccc(Cl)cc1Cl)O2)N1CCOCC1
InChIKey VUCKSZWMRCSPME-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 3
Molecular weight (Da) 491.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D5 DRD5 Human Dopamine A pKi 6.15 6.15 6.15 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 6.22 6.22 6.22 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 6.5 6.5 6.5 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 5.58 5.58 5.58 ChEMBL
κ OPRK Human Opioid A pKi 6.3 6.3 6.3 ChEMBL
CB1 CNR1 Human Cannabinoid A pKi 8.4 8.4 8.4 ChEMBL
μ OPRM Human Opioid A pKi 5.5 5.5 5.5 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
GPR183 GP183 Human Orphan A pIC50 5.45 5.45 5.45 ChEMBL
GPR35 GPR35 Human Orphan A pIC50 5.27 5.27 5.27 ChEMBL
GPR119 GP119 Human GPR18, GPR55 and GPR119 A pIC50 5.5 5.5 5.5 ChEMBL
CB1 CNR1 Human Cannabinoid A pEC50 7.96 7.96 7.96 ChEMBL