(+/-)-NUCIFERINE


SMILES COc1cc2c3c(c1OC)-c1ccccc1CC3N(C)CC2
InChIKey ORJVQPIHKOARKV-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 2
Molecular weight (Da) 295.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D1 DRD1 Rat Dopamine A pKi 6.2 6.21 6.23 ChEMBL
D2 DRD2 Rat Dopamine A pKi 6.68 6.72 6.76 ChEMBL
D2 DRD2 Human Dopamine A pKi 6.76 6.76 6.76 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT7 5HT7R Human 5-Hydroxytryptamine A pEC50 6.82 6.82 6.82 ChEMBL
D1 DRD1 Human Dopamine A pIC50 4.66 4.66 4.66 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pIC50 6.88 6.88 6.88 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pIC50 6.32 6.32 6.32 ChEMBL
D2 DRD2 Human Dopamine A pEC50 7.19 7.19 7.19 ChEMBL
D2 DRD2 Human Dopamine A pIC50 4.83 4.83 4.83 ChEMBL