CHEMBL237394


SMILES CCOc1ccc(-n2ncc(-c3ccc4cc(CCN5CCC[C@H]5C)ccc4n3)c2C)nn1
InChIKey JBAFEJCXHMAIBL-GOSISDBHSA-N

Chemical properties

Hydrogen bond acceptors 7
Hydrogen bond donors 0
Rotatable bonds 7
Molecular weight (Da) 442.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H3 HRH3 Rat Histamine A pKi 9.0 9.23 9.31 ChEMBL
H3 HRH3 Human Histamine A pKi 9.7 9.72 9.73 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H3 HRH3 Rat Histamine A pEC50 9.13 9.13 9.13 ChEMBL
H3 HRH3 Human Histamine A pEC50 9.23 9.23 9.23 ChEMBL