(+)-butaclamol


SMILES O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C
InChIKey ZZJYIKPMDIWRSN-HWBMXIPRSA-N

Chemical properties

Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 0
Molecular weight (Da) 361.2

Drug properties

Molecular type Lipid
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Ligand site mutations D1 D2 D3 D4 D5

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 6.4 6.4 6.4 Guide to Pharmacology
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 8.6 8.6 8.6 Guide to Pharmacology
D1 DRD1 Human Dopamine A pKi 6.5 7.5 8.5 Guide to Pharmacology
D2 DRD2 Human Dopamine A pKi 7.5 8.1 8.7 Guide to Pharmacology
D3 DRD3 Human Dopamine A pKi 6.7 7.35 8.0 Guide to Pharmacology
D4 DRD4 Human Dopamine A pKi 6.3 6.3 6.3 Guide to Pharmacology
D3 DRD3 Rat Dopamine A pKi 7.3 7.4 7.5 Guide to Pharmacology
5-HT7 5HT7R Mouse 5-Hydroxytryptamine A pKi 7.5 7.5 7.5 Guide to Pharmacology
5-HT7 5HT7R Rat 5-Hydroxytryptamine A pKi 7.0 7.0 7.0 Guide to Pharmacology
D1 DRD1 Human Dopamine A pKi 8.37 8.55 8.7 ChEMBL
D3 DRD3 Human Dopamine A pKi 10.4 10.4 10.4 ChEMBL
D2 DRD2 Human Dopamine A pKi 9.04 9.85 10.4 ChEMBL
D5 DRD5 Human Dopamine A pKi 7.6 7.6 7.6 Guide to Pharmacology
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
NPS NPSR1 Human Neuropeptide S A Potency 4.9 4.95 5.0 ChEMBL
D3 DRD3 Human Dopamine A pIC50 7.89 8.35 8.8 ChEMBL
D2 DRD2 Human Dopamine A pIC50 8.57 8.87 9.09 ChEMBL