buserelin


SMILES CCNC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@H](Cc1ccc(cc1)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1)CO)COC(C)(C)C)CC(C)C)CCCN=C(N)N
InChIKey CUWODFFVMXJOKD-UVLQAERKSA-N
Sequence XHWSYSLRP

Chemical properties

Hydrogen bond acceptors 15
Hydrogen bond donors 15
Rotatable bonds 32
Molecular weight (Da) 1238.7

Drug properties

Molecular type Peptide
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
GnRH1 GNRHR Human Gonadotrophin-releasing hormone A pKi 9.4 9.7 10.0 Guide to Pharmacology
GnRH1 GNRHR Human Gonadotrophin-releasing hormone A pKd 9.52 9.96 10.4 Guide to Pharmacology
LH LSHR Human Glycoprotein hormone A pKd 8.07 8.07 8.07 Drug Central
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
GnRH1 GNRHR Human Gonadotrophin-releasing hormone A pEC50 10.52 10.52 10.52 Guide to Pharmacology
GnRH1 GNRHR Mouse Gonadotrophin-releasing hormone A pEC50 9.34 9.7 10.05 Guide to Pharmacology
GnRH1 GNRHR Human Gonadotrophin-releasing hormone A pEC50 7.98 7.98 7.98 Drug Central
GnRH1 GNRHR Mouse Gonadotrophin-releasing hormone A pEC50 8.0 8.0 8.0 Drug Central