brimonidine (UK14304)
| SMILES | Brc1c(ccc2c1nccn2)NC1=NCCN1 |
| InChIKey | XYLJNLCSTIOKRM-UHFFFAOYSA-N |
Chemical properties
| Hydrogen bond acceptors | 5 |
| Hydrogen bond donors | 2 |
| Rotatable bonds | 1 |
| Molecular weight (Da) | 291.0 |
Drug properties
| Molecular type | Small molecule |
| Physiological/Surrogate | Surrogate |
| Approved drug | Yes |
Bioactivities
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
| α2A | ADA2A | Human | Adrenoceptors | A | pKi | 6.4 | 7.55 | 8.7 | Guide to Pharmacology |
| α2B | ADA2B | Human | Adrenoceptors | A | pKi | 5.5 | 6.9 | 8.3 | Guide to Pharmacology |
| α2C | ADA2C | Human | Adrenoceptors | A | pKi | 5.7 | 6.65 | 7.6 | Guide to Pharmacology |
| 5-HT1A | 5HT1A | Human | 5-Hydroxytryptamine | A | pKi | 8.23 | 8.23 | 8.23 | Drug Central |
| α1A | ADA1A | Human | Adrenoceptors | A | pKi | 8.26 | 8.26 | 8.26 | Drug Central |
| α1B | ADA1B | Human | Adrenoceptors | A | pKi | 8.28 | 8.28 | 8.28 | Drug Central |
| α1D | ADA1D | Human | Adrenoceptors | A | pKi | 8.22 | 8.22 | 8.22 | Drug Central |
| α2B | ADA2B | Rat | Adrenoceptors | A | pKi | 8.14 | 8.14 | 8.14 | Drug Central |
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
| α2A | ADA2A | Human | Adrenoceptors | A | pEC50 | 9.1 | 9.1 | 9.1 | Guide to Pharmacology |
| α2A | ADA2A | Human | Adrenoceptors | A | pIC50 | 8.9 | 8.9 | 8.9 | Guide to Pharmacology |
| α2B | ADA2B | Human | Adrenoceptors | A | pEC50 | 7.5 | 7.5 | 7.5 | Guide to Pharmacology |
| α2B | ADA2B | Human | Adrenoceptors | A | pIC50 | 8.4 | 8.4 | 8.4 | Guide to Pharmacology |
| α2C | ADA2C | Human | Adrenoceptors | A | pEC50 | 5.88 | 7.29 | 6.88 | Guide to Pharmacology |
| α2C | ADA2C | Human | Adrenoceptors | A | pIC50 | 8.0 | 8.25 | 8.5 | Guide to Pharmacology |
| α2A | ADA2A | Human | Adrenoceptors | A | pEC50 | 8.08 | 8.08 | 8.08 | Drug Central |
| α2B | ADA2B | Human | Adrenoceptors | A | pEC50 | 8.14 | 8.14 | 8.14 | Drug Central |
| α2C | ADA2C | Human | Adrenoceptors | A | pEC50 | 8.07 | 8.07 | 8.07 | Drug Central |
| 5-HT1A | 5HT1A | Rat | 5-Hydroxytryptamine | A | pIC50 | 8.25 | 8.25 | 8.25 | Drug Central |
| α1A | ADA1A | Bovine | Adrenoceptors | A | pEC50 | 8.23 | 8.23 | 8.23 | Drug Central |