bombesin


SMILES CSCC[C@@H](C(=O)N)NC(=O)[C@@H](NC(=O)[C@H](Cc1nc[nH]c1)NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]1CCC(=O)N1)CCC(=O)N)CCCNC(=N)N)CC(C)C)CC(=O)N)CCC(=O)N)C)CC(C)C
InChIKey QXZBMSIDSOZZHK-DOPDSADYSA-N
Sequence XQRLGNQWAVGHLM

Chemical properties

Hydrogen bond acceptors 21
Hydrogen bond donors 23
Rotatable bonds 51
Molecular weight (Da) 1618.8

Drug properties

Molecular type Peptide
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
BB1 NMBR Human Bombesin A pKi 7.47 7.48 7.49 Guide to Pharmacology
BB2 GRPR Human Bombesin A pKi 7.36 8.11 8.85 Guide to Pharmacology
BB2 GRPR Rat Bombesin A pKi 8.39 8.39 8.39 Guide to Pharmacology
BB1 NMBR Rat Bombesin A pKi 7.47 7.57 7.68 Guide to Pharmacology
BB2 GRPR Human Bombesin A pKi 9.82 9.82 9.82 ChEMBL
BB1 NMBR Human Bombesin A pKi 8.7 8.7 8.7 ChEMBL
BB2 GRPR Mouse Bombesin A pKi 8.17 8.61 9.05 Guide to Pharmacology
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
BB1 NMBR Human Bombesin A pIC50 8.43 8.59 8.75 Guide to Pharmacology
BB2 GRPR Human Bombesin A pIC50 9.77 9.96 10.15 Guide to Pharmacology
BB2 GRPR Human Bombesin A pEC50 9.59 9.59 9.59 ChEMBL
BB2 GRPR Human Bombesin A pIC50 8.7 8.7 8.7 ChEMBL
Y1 NPY1R Human Neuropeptide Y A pIC50 8.33 8.33 8.33 ChEMBL