PALIPERIDONE


SMILES Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O
InChIKey PMXMIIMHBWHSKN-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 7
Hydrogen bond donors 1
Rotatable bonds 4
Molecular weight (Da) 426.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D5 DRD5 Human Dopamine A pKi 7.54 7.54 7.54 ChEMBL
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 8.14 8.14 8.14 ChEMBL
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 6.96 6.96 6.96 ChEMBL
α2B ADA2B Human Adrenoceptors A pKi 8.4 8.4 8.4 ChEMBL
α2C ADA2C Human Adrenoceptors A pKi 8.57 8.57 8.57 ChEMBL
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 8.17 8.17 8.17 ChEMBL
H1 HRH1 Human Histamine A pKi 7.47 7.47 7.47 ChEMBL
D4 DRD4 Human Dopamine A pKi 7.42 7.42 7.42 ChEMBL
α1A ADA1A Human Adrenoceptors A pKi 7.96 7.96 7.96 ChEMBL
α2A ADA2A Human Adrenoceptors A pKi 7.96 7.96 7.96 ChEMBL
D1 DRD1 Human Dopamine A pKi 6.26 6.26 6.26 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 7.72 7.72 7.72 ChEMBL
D3 DRD3 Human Dopamine A pKi 8.12 8.12 8.12 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 9.08 9.08 9.08 ChEMBL
D2 DRD2 Human Dopamine A pKi 8.8 8.8 8.8 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 8.21 8.21 8.21 Drug Central
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 8.12 8.12 8.12 Drug Central
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 8.11 8.11 8.11 Drug Central
5-HT1E 5HT1E Human 5-Hydroxytryptamine A pKi 8.22 8.22 8.22 Drug Central
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 8.05 8.05 8.05 Drug Central
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 8.14 8.14 8.14 Drug Central
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 8.14 8.14 8.14 Drug Central
5-HT5A 5HT5A Human 5-Hydroxytryptamine A pKi 8.18 8.18 8.18 Drug Central
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 8.25 8.25 8.25 Drug Central
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 8.07 8.07 8.07 Drug Central
α1A ADA1A Human Adrenoceptors A pKi 8.07 8.07 8.07 Drug Central
α1B ADA1B Human Adrenoceptors A pKi 8.04 8.04 8.04 Drug Central
α2A ADA2A Human Adrenoceptors A pKi 8.1 8.1 8.1 Drug Central
α2B ADA2B Human Adrenoceptors A pKi 8.12 8.12 8.12 Drug Central
α2C ADA2C Human Adrenoceptors A pKi 8.09 8.09 8.09 Drug Central
β1 ADRB1 Human Adrenoceptors A pKi 8.28 8.28 8.28 Drug Central
β2 ADRB2 Human Adrenoceptors A pKi 8.28 8.28 8.28 Drug Central
D1 DRD1 Human Dopamine A pKi 8.13 8.13 8.13 Drug Central
D2 DRD2 Human Dopamine A pKi 8.07 8.07 8.07 Drug Central
D3 DRD3 Human Dopamine A pKi 8.04 8.04 8.04 Drug Central
D5 DRD5 Human Dopamine A pKi 8.12 8.12 8.12 Drug Central
H1 HRH1 Human Histamine A pKi 8.08 8.08 8.08 Drug Central
H2 HRH2 Human Histamine A pKi 8.16 8.16 8.16 Drug Central
H4 HRH4 Human Histamine A pKi 8.3 8.3 8.3 Drug Central
EP3 PE2R3 Human Prostanoid A pKi 8.3 8.3 8.3 Drug Central
D4 DRD4 Human Dopamine A pKi 8.14 8.14 8.14 Drug Central
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pIC50 8.28 8.28 8.28 ChEMBL
D2 DRD2 Human Dopamine A pIC50 8.08 8.08 8.08 ChEMBL