azelastine


SMILES CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2
InChIKey MBUVEWMHONZEQD-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 3
Molecular weight (Da) 381.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H1 HRH1 Human Histamine A pKi 8.9 8.9 8.9 Guide to Pharmacology
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 5.37 5.37 5.37 ChEMBL
α1B ADA1B Human Adrenoceptors A pKi 5.44 6.93 7.3 ChEMBL
α2B ADA2B Human Adrenoceptors A pKi 6.64 6.64 6.64 ChEMBL
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 6.41 6.41 6.41 ChEMBL
H1 HRH1 Human Histamine A pKd 9.7 9.7 9.7 ChEMBL
H1 HRH1 Human Histamine A pKi 8.9 8.92 8.96 ChEMBL
α1A ADA1A Human Adrenoceptors A pKi 6.3 7.1 7.3 ChEMBL
α2A ADA2A Human Adrenoceptors A pKi 5.84 5.84 5.84 ChEMBL
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 5.68 5.68 5.68 ChEMBL
D1 DRD1 Human Dopamine A pKi 6.24 6.24 6.24 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 7.7 7.7 7.7 ChEMBL
H3 HRH3 Human Histamine A pKi 6.8 6.82 6.83 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 6.3 6.3 6.3 ChEMBL
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 5.37 5.37 5.37 ChEMBL
D3 DRD3 Human Dopamine A pKi 6.2 6.2 6.2 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 6.64 6.64 6.64 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 8.11 8.11 8.11 Drug Central
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 8.2 8.2 8.2 Drug Central
α1A ADA1A Human Adrenoceptors A pKi 8.14 8.14 8.14 Drug Central
α1B ADA1B Human Adrenoceptors A pKi 8.14 8.14 8.14 Drug Central
H1 HRH1 Human Histamine A pKi 8.09 8.09 8.09 Drug Central
H3 HRH3 Human Histamine A pKi 8.17 8.17 8.17 Drug Central
α1A ADA1A Rat Adrenoceptors A pKi 8.14 8.14 8.14 Drug Central
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 6.05 6.05 6.05 ChEMBL
5-HT1E 5HT1E Human 5-Hydroxytryptamine A pKi 5.27 5.27 5.27 ChEMBL
α1D ADA1D Human Adrenoceptors A pKi 6.48 6.48 6.48 ChEMBL
D2 DRD2 Human Dopamine A pKi 5.93 5.93 5.93 ChEMBL
α1A ADA1A Rat Adrenoceptors A pKi 7.3 7.3 7.3 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
M1 ACM1 Human Acetylcholine (muscarinic) A pIC50 5.2 5.2 5.2 ChEMBL
M1 ACM1 Human Acetylcholine (muscarinic) A pIC50 8.28 8.28 8.28 Drug Central