AZD5069


SMILES OC[C@@H]([C@H](Oc1nc(SCc2cccc(c2F)F)nc(c1)NS(=O)(=O)N1CCC1)C)O
InChIKey QZECRCLSIGFCIO-RISCZKNCSA-N

Chemical properties

Hydrogen bond acceptors 8
Hydrogen bond donors 3
Rotatable bonds 10
Molecular weight (Da) 476.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
CXCR1 CXCR1 Human Chemokine A pKd 9.4 9.4 9.4 ChEMBL
CXCR2 CXCR2 Human Chemokine A pKi 9.61 9.61 9.61 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
CXCR1 CXCR1 Human Chemokine A pIC50 6.9 6.9 6.9 Guide to Pharmacology
CXCR2 CXCR2 Human Chemokine A pIC50 9.1 9.1 9.1 Guide to Pharmacology
CXCR2 CXCR2 Human Chemokine A pIC50 8.49 8.49 8.49 ChEMBL